The Evidence-Based Benefits of Multivitamins: What the Science Actually Supports

The Evidence-Based Benefits of Multivitamins: What the Science Actually Supports

One minute it’s coconut oil in everything, the next it’s some trendy berry powder claiming to change your life. But through all the fads, multivitamins have quietly stuck around.

You’ll find them in kitchens up and down the country, tucked beside the tea bags, next to the cereal boxes, or perched by the kettle as a daily reminder to pop them down with breakfast.

So why do so many of us still take them? What are they actually doing for our health, and which claims are reliably backed by science?

This article explores the proven benefits of multivitamins based on authorised health claims from the European Food Safety Authority (EFSA) and the UK’s Medicines and Healthcare products Regulatory Agency (MHRA). These are not speculative claims, they’re legally recognised and backed by robust scientific data.

To make it easier to navigate, we’ve grouped the health benefits into categories based on how multivitamins support various aspects of human health.

Table of Contents

    Energy, Metabolism and Fatigue

    Supporting energy production

    Multivitamins play a vital role in how the body generates energy. While they don’t provide energy directly like calories from food, they act as coenzymes and cofactors that drive the metabolic processes required to extract energy from carbohydrates, fats and proteins. Vitamins such as biotin, niacin, pantothenic acid, riboflavin, thiamine, vitamin B6, B12 and C, along with minerals like iron, iodine, copper and phosphorus, contribute to normal energy-yielding metabolism.

    These micronutrients help convert food into ATP, the body’s primary energy currency, supporting everything from basic cellular function to physical performance and mental alertness.

    Combating tiredness and fatigue

    A deficiency in certain B vitamins, iron or vitamin C can lead to symptoms of tiredness and reduced stamina. Clinical evidence supports the role of vitamin B2 (riboflavin), vitamin B6, vitamin B12, folate, vitamin C, pantothenic acid, niacin and iron in reducing tiredness and fatigue, helping you feel more energised and mentally alert throughout the day.

    Brain, Nerve and Psychological Function

    Nervous system health

    The nervous system relies on several vitamins and minerals for healthy function. Thiamine, riboflavin, niacin, biotin, vitamin B6, B12 and C, as well as iodine, copper, potassium and magnesium, all contribute to the normal functioning of the nervous system. These nutrients are involved in neurotransmitter synthesis, nerve signalling and maintaining the structural integrity of neurons.

    Psychological wellbeing and cognitive support

    Mental clarity and mood are also dependent on nutritional status. Biotin, folate, niacin, thiamine, vitamin B6, B12 and C are all recognised for their contribution to normal psychological function. Meanwhile, iodine, iron and zinc contribute to normal cognitive function, influencing memory, concentration and learning.

    Immune Health and Antioxidant Defence

    Supporting immune defences

    Vitamin C is the greatest celebrity when it comes to supporting the immune system but, in reality, there are other nutrients known to be more important. One of the most influential vitamins for the immune system is actually vitamin A. So don’t just turn to oranges when you catch a cold - you need carrots as well!

    In fact, an effective immune system requires a well-nourished body. Vitamins A, B6, B12, C, D and folate, along with copper, selenium, zinc and iron, are all known to contribute to the normal function of the immune system. Vitamin D plays an additional role in supporting immune health in children, while vitamin C helps maintain immune function during and after intense physical exercise.

    Protection against oxidative stress

    Many essential nutrients function as antioxidants, helping to neutralise free radicals and reduce cellular damage. Vitamins C and E, along with riboflavin, copper, selenium and zinc, contribute to the protection of cells from oxidative stress, thereby supporting long-term health and slowing cellular ageing.

    Skin, Hair and Nail Health

    Maintaining healthy skin and mucous membranes

    You know the answer to this, right? Vitamin E? Nope! Oddly enough, whilst this vitamin hogs the limelight for skin health, it's actually not one of the vitamins proven to have any benefits specifically for the skin. 

    By don't panic, because your multivitamin supplement has plenty of other vitamins that will take care of your skin. Several vitamins and minerals support the structure, hydration and integrity of the skin and mucous membranes. Niacin, riboflavin, vitamin A, biotin, iodine and zinc contribute to the maintenance of normal skin. Biotin, niacin and riboflavin also help maintain normal mucous membranes, such as those lining the mouth, nose and digestive tract. Copper and zinc are involved in skin pigmentation processes, further supporting a healthy, even complexion.

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    Hair and nail support

    Biotin, selenium and zinc are well-established for their role in maintaining healthy hair. Copper contributes to normal hair pigmentation, while selenium and zinc also help maintain strong, healthy nails. These nutrients support keratin production and protect against breakage and brittleness.

    Bone, Joint and Dental Support

    Strong bones and teeth

    Healthy bones and teeth rely on more than just calcium. Phosphorus, magnesium, vitamin D and vitamin K all contribute to the maintenance of normal bones, while calcium, phosphorus and vitamin D help maintain normal teeth. Vitamin D is also essential for the absorption and utilisation of calcium and phosphorus, making it critical for overall skeletal integrity.

    Cartilage and joint structure

    Vitamin C plays an important role in collagen formation, which supports the normal function of cartilage. This is essential for joint flexibility, shock absorption and long-term mobility.

    Bone health in older adults and children

    Phosphorus supports the normal growth and development of bones in children. Vitamin D also plays a dual role, contributing to normal bone development in children and reducing the risk of falling in adults over 60, particularly important as falls are a major risk factor for bone fractures in older populations.

    Muscle and Cardiovascular Function

    Muscle performance

    Muscle health isn’t just about protein intake. Vitamin D and potassium contribute to the maintenance of normal muscle function. These nutrients help regulate muscle contraction and support the repair and regeneration of muscle fibres.

    Heart health and circulation

    Thiamine contributes to the normal function of the heart. Iron is vital for forming haemoglobin and supporting the transport of oxygen throughout the body. Potassium contributes to the maintenance of normal blood pressure, while vitamin C supports collagen formation in blood vessel walls, promoting healthy circulation.

    Hormonal Health and Fertility

    Hormone production and regulation

    Vitamin B6 plays a specific role in the regulation of hormonal activity, influencing mood, metabolism and reproductive function. Pantothenic acid contributes to the synthesis and metabolism of steroid hormones, vitamin D and neurotransmitters, making it essential for hormonal balance.

    Fertility and reproductive support

    Zinc contributes to normal fertility and reproduction, while selenium supports normal sperm production (spermatogenesis), making these minerals particularly important for reproductive health in both men and women.

    Liver Function and Detoxification

    The liver is responsible for detoxifying the body, processing hormones and managing lipid metabolism. Choline contributes to the maintenance of normal liver function and supports normal lipid metabolism. In addition, choline, folate, vitamin B6 and B12 contribute to normal homocysteine metabolism, which is important for vascular and neurological health.

    Blood Formation and Oxygen Transport

    Iron, vitamin B6, B12, riboflavin and folate are all critical for normal red blood cell formation. Iron contributes to the production of haemoglobin, which is essential for carrying oxygen throughout the body. Vitamin A supports normal iron metabolism, while vitamin C increases iron absorption, an important consideration for those prone to iron deficiency.

    During pregnancy, folate contributes to normal blood formation and supports maternal tissue growth. Supplemental folic acid increases maternal folate status and helps reduce the risk of neural tube defects in the developing foetus.

    Growth, Development and Cell Division

    Children, pregnant women and anyone recovering from illness all have increased needs for nutrients that support growth and cell regeneration. Iron, iodine, phosphorus and vitamin D contribute to the normal growth and development of children. Folate, iron, vitamin B12, vitamin D, vitamin A and zinc are all involved in the process of cell division, while vitamin A also contributes to normal cell specialisation.

    These functions are essential not only for early development, but also for tissue repair, immune resilience and long-term vitality.

    Vision and Eye Health

    Vision is another area where nutrition plays a key role. Vitamin A, riboflavin and zinc all contribute to the maintenance of normal vision. These nutrients help protect the retina, support the cornea and reduce the risk of age-related eye conditions.

    Skin Barriers and Mucosal Immunity

    Beyond the visible skin surface, mucous membranes form an important line of defence against pathogens. Biotin, niacin, riboflavin and vitamin A contribute to the maintenance of normal mucous membranes. These include the linings of the respiratory, gastrointestinal and reproductive tracts, key sites for immune activity and nutrient absorption.

    Connective Tissue and Pigmentation

    Copper supports the maintenance of normal connective tissues, which include skin, ligaments, tendons and cartilage. It also contributes to the pigmentation of skin and hair and plays a role in transporting iron within the body, ensuring its availability for red blood cell production and oxygen transport.

    Why Multivitamins Matter

    Given the vast number of essential functions they support, it’s easy to see why multivitamins remain a popular supplement. While they should never replace a balanced diet, they offer a reliable way to help cover nutritional gaps, particularly in people with restricted diets, increased physiological demands or compromised absorption.

    Populations that may benefit from a multivitamin include older adults, vegans and vegetarians, people with food allergies or intolerances, women who are pregnant or breastfeeding, and individuals under chronic stress or recovering from illness.

    Conclusion

    Multivitamins are far more than a nutritional safety net. Backed by regulatory authorities such as the EFSA and MHRA, the vitamins and minerals in a well-formulated multivitamin are proven to contribute to dozens of vital processes, from energy metabolism and immunity to cognitive performance, bone health, fertility and beyond.

    Choosing a multivitamin with clear, evidence-based claims ensures you're investing in your health with confidence. Whether you're aiming to support daily wellbeing, prepare for pregnancy, or simply feel your best, a quality multivitamin can be a valuable investment.

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    Veronica Hughes

    Veronica Hughes is a writer and researcher with a lifelong passion for nutrition and healthcare. She has spearheaded a medical research charity as its CEO, been an influential committee member of National Institute of Health and Care Excellence (NICE) to shape treatment guidelines for the NHS, and actively contributed to the development of Care Quality Commission treatment standards for the NHS. Her publications include newspaper articles and insightful blogs covering a spectrum of health topics, ranging from diseases and nutrition to modern healthcare and groundbreaking medical research.

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